Prior Infection and Passive Transfer of Neutralizing Antibody Prevent Replication of Severe Acute Respiratory Syndrome Coronavirus in the Respiratory Tract of Mice
Identifieur interne : 001560 ( Pmc/Checkpoint ); précédent : 001559; suivant : 001561Prior Infection and Passive Transfer of Neutralizing Antibody Prevent Replication of Severe Acute Respiratory Syndrome Coronavirus in the Respiratory Tract of Mice
Auteurs : Kanta Subbarao ; Josephine Mcauliffe ; Leatrice Vogel ; Gary Fahle ; Steven Fischer ; Kathleen Tatti ; Michelle Packard ; Wun-Ju Shieh ; Sherif Zaki ; Brian MurphySource :
- Journal of Virology [ 0022-538X ] ; 2004.
Abstract
Following intranasal administration, the severe acute respiratory syndrome (SARS) coronavirus replicated to high titers in the respiratory tracts of BALB/c mice. Peak replication was seen in the absence of disease on day 1 or 2, depending on the dose administered, and the virus was cleared within a week. Viral antigen and nucleic acid were detected in bronchiolar epithelial cells during peak viral replication. Mice developed a neutralizing antibody response and were protected from reinfection 28 days following primary infection. Passive transfer of immune serum to naïve mice prevented virus replication in the lower respiratory tract following intranasal challenge. Thus, antibodies, acting alone, can prevent replication of the SARS coronavirus in the lung, a promising observation for the development of vaccines, immunotherapy, and immunoprophylaxis regimens.
Url:
DOI: 10.1128/JVI.78.7.3572-3577.2004
PubMed: 15016880
PubMed Central: 371090
Affiliations:
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first="Gary" last="Fahle">Gary Fahle</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Fischer, Steven" sort="Fischer, Steven" uniqKey="Fischer S" first="Steven" last="Fischer">Steven Fischer</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tatti, Kathleen" sort="Tatti, Kathleen" uniqKey="Tatti K" first="Kathleen" last="Tatti">Kathleen Tatti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Packard, Michelle" sort="Packard, Michelle" uniqKey="Packard M" first="Michelle" last="Packard">Michelle Packard</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Murphy, Brian" sort="Murphy, Brian" uniqKey="Murphy B" first="Brian" last="Murphy">Brian Murphy</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Following intranasal administration, the severe acute respiratory syndrome (SARS) coronavirus replicated to high titers in the respiratory tracts of BALB/c mice. Peak replication was seen in the absence of disease on day 1 or 2, depending on the dose administered, and the virus was cleared within a week. Viral antigen and nucleic acid were detected in bronchiolar epithelial cells during peak viral replication. Mice developed a neutralizing antibody response and were protected from reinfection 28 days following primary infection. Passive transfer of immune serum to naïve mice prevented virus replication in the lower respiratory tract following intranasal challenge. Thus, antibodies, acting alone, can prevent replication of the SARS coronavirus in the lung, a promising observation for the development of vaccines, immunotherapy, and immunoprophylaxis regimens.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">jvi</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15016880</article-id><article-id pub-id-type="pmc">371090</article-id><article-id pub-id-type="publisher-id">2225</article-id><article-id pub-id-type="doi">10.1128/JVI.78.7.3572-3577.2004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>Prior Infection and Passive Transfer of Neutralizing Antibody Prevent Replication of Severe Acute Respiratory Syndrome Coronavirus in the Respiratory Tract of Mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Subbarao</surname><given-names>Kanta</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>McAuliffe</surname><given-names>Josephine</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vogel</surname><given-names>Leatrice</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fahle</surname><given-names>Gary</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Fischer</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Tatti</surname><given-names>Kathleen</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Packard</surname><given-names>Michelle</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Shieh</surname><given-names>Wun-Ju</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Zaki</surname><given-names>Sherif</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Murphy</surname><given-names>Brian</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases,<label>1</label> Microbiology Service, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892,<label>2</label> Infectious Disease Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333<label>3</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: Laboratory of Infectious Diseases, NIAID, Bldg. 50, Room 6132, 50 South Dr., MSC 8007, Bethesda, MD 20892. Phone: (301) 451-3839. Fax: (301) 496-8312. E-mail: <email>Ksubbarao@niaid.nih.gov</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>2004</year></pub-date><volume>78</volume><issue>7</issue><fpage>3572</fpage><lpage>3577</lpage><history><date date-type="received"><day>21</day><month>10</month><year>2003</year></date><date date-type="accepted"><day>10</day><month>11</month><year>2003</year></date></history><copyright-year>2004</copyright-year><abstract><p>Following intranasal administration, the severe acute respiratory syndrome (SARS) coronavirus replicated to high titers in the respiratory tracts of BALB/c mice. Peak replication was seen in the absence of disease on day 1 or 2, depending on the dose administered, and the virus was cleared within a week. Viral antigen and nucleic acid were detected in bronchiolar epithelial cells during peak viral replication. Mice developed a neutralizing antibody response and were protected from reinfection 28 days following primary infection. Passive transfer of immune serum to naïve mice prevented virus replication in the lower respiratory tract following intranasal challenge. Thus, antibodies, acting alone, can prevent replication of the SARS coronavirus in the lung, a promising observation for the development of vaccines, immunotherapy, and immunoprophylaxis regimens.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Fahle, Gary" sort="Fahle, Gary" uniqKey="Fahle G" first="Gary" last="Fahle">Gary Fahle</name><name sortKey="Fischer, Steven" sort="Fischer, Steven" uniqKey="Fischer S" first="Steven" last="Fischer">Steven Fischer</name><name sortKey="Mcauliffe, Josephine" sort="Mcauliffe, Josephine" uniqKey="Mcauliffe J" first="Josephine" last="Mcauliffe">Josephine Mcauliffe</name><name sortKey="Murphy, Brian" sort="Murphy, Brian" uniqKey="Murphy B" first="Brian" last="Murphy">Brian Murphy</name><name sortKey="Packard, Michelle" sort="Packard, Michelle" uniqKey="Packard M" first="Michelle" last="Packard">Michelle Packard</name><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Tatti, Kathleen" sort="Tatti, Kathleen" uniqKey="Tatti K" first="Kathleen" last="Tatti">Kathleen Tatti</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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